Patterns of single-neuron activity during associative recognition memory in the human medial temporal lobe
- Derner, Marlene ORCID University of Bonn
- Dehnen, Gert (Contributor) University of Bonn
- Chaieb, Leila (Contributor) ORCID University of Bonn
- Reber, Thomas P. (Contributor) ORCID UniDistance Suisse
- Borger, Valeri (Contributor) ORCID University of Bonn
- Surges, Rainer (Contributor) ORCID University of Bonn
- Staresina, Bernhard P. (Contributor) ORCID University of Birmingham
- Mormann, Florian (Contributor) ORCID University of Bonn
- Fell, Juergen (Contributor) ORCID University of Bonn
- 2020
Published in:
- NeuroImage. - Academic Press. - 2020, vol. 221, p. 117214
English
Electrophysiological activity in medial temporal lobe (MTL) structures is pivotal for declarative long-term mem- ory. Single-neuron and microcircuit findings capitalizing on human microwire recordings from the medial tem- poral lobe are still fragmentary. In particular, it is an open question whether identical or different groups of neurons participate in different memory functions. Here, we investigated category-specific responses in the hu- man MTL based on single-neuron recordings in presurgical epilepsy patients performing an associative long-term memory task. Additionally, auditory beat stimuli were presented during encoding and retrieval to modulate memory performance. We describe the proportion of neurons in amygdala, entorhinal cortex, hippocampus and parahippocampal cortex belonging to different response classes. These entail neurons coding stimulus-familiarity, neurons coding successful item memory, and neurons coding associated source memory, as well as the overlap between these classes. As major results we demonstrate that neurons responding to stimulus familiarity (old/new effect) can be identified in the MTL even when using previously known rather than entirely novel stimulus ma- terial (words). We observed a significant overlap between familiarity-related neurons and neurons coding item retrieval (remembered/forgotten effect). The largest fraction of familiarity-related neurons was found in the parahippocampal cortex, and a considerable fraction of all parahippocampal neurons was related to successful item retrieval. Neurons related to successful source retrieval were different from the neurons coding the associ- ated information. Most importantly, there was no overlap between neurons coding item memory and those coding associated source memory strongly suggesting that these functions are facilitated by different sets of neurons.
- Language
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- English
- Classification
- Psychology
- License
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CC BY-NC-ND
- Identifiers
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- DOI 10.1016/j.neuroimage.2020.117214
- ARK ark:/51647/srd1323889
- Persistent URL
- https://n2t.net/ark:/51647/srd1323889
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